Description
Today, many drug targets are challenging when it comes to affinity screening, as immobilization requirements complicate assay development. SPR struggles with applications involving PROTAC binary and ternary complexes, intrinsically disordered proteins, and covalent binders. These are precisely the applications where Dianthus excels.
Dianthus is a plate-based and microfluidics-free affinity screening platform. Measurements are performed in solution and are mass-independent — ideal for succeeding at demanding screening campaigns. With two methods for measuring molecular interactions, Spectral Shift and TRIC, Dianthus delivers high-quality data and requires less assay development to give you results from real-life samples. Its 384-well format and gRPC framework means it can be seamlessly integrated into any automation solutions that include robotic liquid handling and plate feeders, for hours of uninterrupted and unattended operation.
Here’s what makes Dianthus the perfect choice for challenging affinity screening campaigns:
- High signal-to-noise ratio: Reliable affinity measurements
- Mass independence: Measure binding with small and large molecules
- Broad range of affinities: From picomolar to millimolar for detection of strong and weak binders
- In-depth understanding of sample quality: Insights into aggregation induced by ligand